颅底的损害及其外科治疗是否会引起癫痫性发作?
Clinical Neurology and NeurosurgeryVolume 109, Issue 5, June 2007, Pages 406-408
Do skull base lesions and their surgical treatment cause epileptic seizures?
颅底的损害及其外科治疗是否会引起癫痫性发作?
Sigmund Jenssena, , , Samuel L. Potolicchiob and Laligam N. Sekharc, 1,
aDepartment of Neurology, Drexel Medical College, Philadelphia, PA, United States
bDepartment of Neurology, George Washington University, Washington, DC, United States
cDepartment of Neurosurgery, University of Washington, United States
Received 18 December 2006; revised 24 January 2007; accepted 15 February 2007. Available online 30 March 2007.
Abstract
Objectives
Few reports exist on the risk of seizures with skull base lesions and their surgical treatment.
目的:在颅底损伤及其外科治疗对癫痫发作的危险性上罕有报道
Patients and methods
All patients referred for surgery of a skull base lesion at George Washington University Hospital from January 1998 to August 1999 were reviewed. After excluding patients with other risk factors 136 patients were included.
病人及方法:自1998年1月至1999年8月在乔滞华盛顿大学医院因为颅底损伤接受外科治疗的病人,除外具有其他危险因素的,共包含有136病例
Results
No seizures were reported before or after surgery, but 59 patients (43%) were taking anticonvulsants. Only 17 (12.5%) had EEG. Four of these showed no abnormalities, 2 were abnormal without sharp waves and 11 had sharp waves (an increase compared to the general population). Most sharp waves affected the temporal lobe on the side of surgery. All EEGs were performed less than 4 months after surgery.
结果:在手术前后均无癫痫发作的报道,但59个病人(43%)在使用抗惊厥药物,只有17位病人(12.5%)做了脑电图,其中4人没有发现异常,2人无尖波,11人具有尖波(比一般人群多).大多数尖波出现于手术侧的颞叶.所有的脑电图均在手术后4个月内完成.
Conclusion
This study does not indicate that seizures are common in this patient group, but there was an increased amount of epileptiform activity on EEG and many patients were taking AED. A prospective study with systematic patient interviews, pre- and post-surgical EEG and a longer follow up is needed
结论:研究没有表明在此群体中癫痫发作是普遍的,但是具有癫痫样的脑电图表现的增多,且许多病人在使用抗癫痫药,一个具有系统的病人检查,术前术后的脑电图及更长时间的随访的前瞻性研究是必要的.
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