经期偏头痛新治疗——Rizatriptan（利扎曲坦）
一，曲坦类药物（5HT受体激动剂）可能通过以下三种途径对头痛起治疗：刺激血管5-HT1B受体使血管收缩
通过刺激三叉神经的突触前5-HT1D受体抑制硬膜的神经原性炎症反应和血浆外渗
通过刺激脑干的5-HT1B或5-HT1D受体抑制三叉神经核的兴奋
二,偏头痛暂无根治药，目前国内上市的治疗偏头痛特异性曲坦类药物有：
第一代的舒马曲坦Sumatrijptan（尤舒）
第二代的苯甲酸利扎曲坦胶囊Rizatriptan（欣渠）
上海瑞金医院药房有售02164370045—663031。二军大长征医院凤阳药店021—63591955
可以快速缓解头痛及其伴随症状，多次服用可以减少发作频率。(《中国新药与临床杂志》2005年3月第24卷第3期)
三，曲坦类药物为受体激动剂，无药物依赖和成瘾性,是治疗偏头痛的特异性药物，对经期头痛和丛集性头痛仍然有效
Cephalalgia. 2007 May;27(5):414-21.
Headache Associates and ClinExcel Research, West Chester, OH 45069, USA. [email]lkmannixmd@aol.com[/email]
These are the first prospective studies to use criteria for menstrual migraine proposed in the 2004 revision of the International Classification of Headache Disorders (ICHD-II) to examine the efficacy of rizatriptan for treatment of a menstrual attack. Two identical protocols (MM1 and MM2) were randomized, parallel, placebo-controlled, double-blind studies. Adult women with ICHD-II menstrual migraine were assigned to either rizatriptan 10-mg tablet or placebo in a 2 : 1 ratio. Patients treated a single menstrual migraine attack of moderate or severe pain intensity. The primary end-point was 2-h pain relief and the secondary end-point was 24-h sustained pain relief. A total of 707 patients (MM1 357, MM2 350) treated a menstrual migraine attack. The percentage of patients reporting 2-h pain relief was significantly greater for rizatriptan than for placebo (MM1 70% vs. 53%, MM2 73% vs. 50%), as was the percentage of patients reporting 24-h sustained pain relief (MM1 46% vs. 33%; MM2 46% vs. 33%). Rizatriptan 10 mg was effective for the treatment of ICHD-II menstrual migraine, as measured by 2-h pain relief and 24-h sustained pain relief.
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