新书推荐：Prodrugs: Challenges and Rewards
Prodrugs (Part 1): Challenges and RewardsBy Valentino J. Stella, Ronald T. Borchardt , Michael J. Hageman , Reza Oliyai
Publisher: Springer
Number Of Pages: 1470
Publication Date: 2007-03-12
ISBN / ASIN: 038749782X
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Book Description:
Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs.
Part I
A Case for Prodrugs ................................................................................3
Valentino J. Stella
Part II - Problems Addressable by Prodrugs
Permeability
Prodrug Approaches to Enhancing
the Oral Delivery of Poorly Permeable Drugs ..............................37
Valentino J. Stella
Topical Delivery Using Prodrugs ..................................................83
Kenneth B. Sloan and Scott C. Wasdo
Prodrug Approaches to Ophthalmic Drug Delivery ..................125
Tomi J鋜vinen and Riku Niemi
Solubility
Oral Delivery ................................................................................158
Tycho Heimbach, David Fleisher, and Amal Kaddoumi
Prodrugs and Parenteral Drug Delivery .....................................217
Jeffery Hemenway and Valentino J. Stella
Metabolism
Poly (ethylene glycol) Prodrugs: Altered
Pharmacokinetics and Pharmacodynamics ................................283
Richard B. Greenwald and Hong Zhao
Prodrugs to Reduce Presystemic Metabolism ............................339
Bruce J. Aungst and Nicole Matz
Controlled Release
Small Molecules ............................................................................357
Jaymin C. Shah
Controlled Release – Macromolecular Prodrugs ........................379
Claus Larsen, Jesper 豷tergaard and Susan W. Larsen
Proenzymes ...................................................................................417
Richard L. Schowen
Targeting
Targeting: Theoretical and Computational Models ...................429
Roger A. Rajewski and Michelle P. McIntosh
Cancer—Small Molecules ............................................................447
Vincent (F.M.H.) de Groot
Monoclonal Antibody Drug Conjugates for Cancer Therapy ....507
Peter D. Senter and Damon L. Meyer
Antibody-Directed Enzyme Prodrug Therapy (ADEPT) ............525
Kenneth D. Bagshawe
Prodrugs for Liver-Targeted Drug Delivery ................................541
Mark D. Erion
Prodrug Approaches for Drug Delivery to the Brain .................573
Bradley D. Anderson
Lymphatic Absorption of Orally Administered Prodrugs .........653
David M. Shackleford, Christopher J.H. Porter and William N. Charman
Colonic Delivery ..........................................................................683
Fumitoshi Hirayama and Kaneto Uekama
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