Cancer Chemoprevention: Volume 2 全书下载
[hide=10][hide]Cancer Chemoprevention: Volume 2: Strategies for Cancer Chemoprevention (Cancer Drug Discovery and Development)By Gary J. Kelloff (Editor), Ernest T. Hawk (Editor), Caroline C. Sigman (Editor)
Publisher: Humana Press
Number Of Pages: 568
Publication Date: 2005-02-01
ISBN / ASIN: 1588290778
Book Description:
Leading researchers comprehensively describe the exciting methodologies that are accelerating progress in chemoprevention and review the state of clinical development of preventive agents in the major human cancer target organs. The authors provide sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design. The emphasis is on documenting the characterization and application of reliable biomarkers during chemopreventive drug development. Highlights include an elegant approach to identifying chemopreventive agents in natural products, the development of preclinical models for evaluating potential chemopreventive agents, the genomics and proteomics of potential applications, and approaches for determining which populations will likely benefit from chemopreventive intervention. A companion volume, Promising Cancer Chemopreventive Agents, comprehensively surveys those agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis.
Preface ........................................................................................................................................................... v
Contributors ................................................................................................................................................. xv
Value-Added eBook/PDA ....................................................................................xix
Color Plates .............................................................................................................xxi
PART I. CHEMOPREVENTIVE AGENT DEVELOPMENT SCIENCE
1 Characterization of Natural Product Chemopreventive Agents ............................................. 3
John M. Pezzuto, Jerome W. Kosmeder II, Eun-Jung Park, Sang Kook Lee, Muriel Cuendet,
Joell Gills, Krishna Bhat, Simonida Grubjesic, Hye-Sung Park, Eugenia Mata-Greenwood,
YingMeei Tan, Rong Yu, Daniel D. Lantvit, and A. Douglas Kinghorn
2 Preclinical Animal Models for the Development of Cancer Chemoprevention Drugs ................ 39
Vernon E. Steele, Ronald A. Lubet, and Richard C. Moon
3 Potential Use of Transgenic Mice in Chemoprevention Studies.......................................... 47
Ronald A. Lubet, Jeffrey Green, Vernon E. Steele, and Ming You
4 Modeling Human Colorectal Cancer in Mice for Chemoprevention Studies .......................... 57
Martin Lipkin and Sergio A. Lamprecht
5 Pathology of Incipient Neoplasia ......................................................................... 69
Donald Earl Henson and Jorge Albores-Saavedra
6 Quantitative Nuclear Grade: Clinical Applications of the Quantitative Measurement
of Nuclear Structure Using Image Analysis ................................................................................................... 97
Robert W. Veltri, Alan W. Partin, and M. Craig Miller
7 Enabling Discovery Through Online Cancer Genome Databases and Analytic Tools ........... 109
Robert L. Strausberg and Gregory J. Riggins
8 Functional Genomics for Identifying Surrogate Endpoint Biomarkers in Breast Cancer Chemoprevention ........ 115
Melissa A. Troester and Charles M. Perou
9 Clinical Applications of Proteomics ....................................................... 123
Emanuel F. Petricoin III and Lance A. Liotta
10 Bioinformatics and Whole-Genome Technologies .......................................................... 131
Richard Simon
11 Models of Absolute Risk: Uses, Estimation, and Validation ..................................... 137
Mitchell H. Gail
12 Genetic Polymorphisms and Risk Assessment for Cancer Chemoprevention ............ 141
Sonia de Assis and Peter G. Shields
13 Design Issues in Prostate Cancer Chemoprevention Trials: Lessons From the Prostate Cancer
Prevention Trial .......................................................................................................................................... 153
Ian M. Thompson and Charles A. Coltman Jr.
14 Recruitment Strategies for Cancer Prevention Trials ..................................... 163
Paul P. Carbone, Karen Sielaff, Mary Hamielec, and Howard Bailey
PART II. CANCER CHEMOPREVENTION AT MAJOR CANCER TARGET SITES
PROSTATE
15 Prostate Cancer Prevention ......................................................................... 185
William G. Nelson, Angelo M. de Marzo, and Scott M. Lippman
16 Use of PSA to Evaluate Risk and Progression of Prostate Cancer .............................. 205
Bulent Akduman, Abelardo Errejon, and E. David Crawford
BREAST
17 Clinical Approaches to Discovering and Testing New Breast Cancer Prevention Drugs .... 213
Carol J. Fabian, Bruce F. Kimler, Matthew S. Mayo, William E. Grizzle, Shahla Masood,
and Giske Ursin
18 Ductal Lavage: Its Role in Breast Cancer Risk Assessment and Risk Reduction .... 239
Joyce O’Shaughnessy and Andrea Decensi
19 Counteracting Estrogen as Breast Cancer Prevention ............................ 249
Kathrin Strasser-Weippl and Paul E. Goss
COLORECTAL
20 Chemoprevention of Colorectal Cancer: Clinical Strategies ............................. 267
Monica M. Bertagnolli and Stanley R. Hamilton
21 Screening in Risk Evaluation and Prevention of Colorectal Cancer ................ 287
Bernard Levin
LUNG
22 Strategies in Lung Cancer Chemoprevention ........................... 297
Edward S. Kim, Faye M. Johnson, Waun Ki Hong, and Fadlo R. Khuri
23 Lung Cancer Chemoprevention: An Opportunity for Direct Drug Delivery .......... 305
James L. Mulshine and Luigi M. De Luca
BLADDER
24 Bladder Cancer: Clinical Strategies for Cancer Chemoprevention .................. 315
H. Barton Grossman, Anita L. Sabichi, and Yu Shen
ESOPHAGUS
25 Barrett’s Esophagus: Strategies for Cancer Prevention ........................... 325
Brian J. Reid
26 Endoscopic Detection of Esophageal Neoplasia ....................................................... 343
Brian C. Jacobson and Jacques Van Dam
27 Chemoprevention Strategies for Esophageal Squamous Cell Carcinoma ............. 353
Paul J. Limburg, Philip R. Taylor, and Sanford M. Dawsey
HEAD AND NECK
28 Chemoprevention of Upper Aerodigestive Tract Cancer: Clinical Trials and Future Directions .... 371
Fadlo R. Khuri, Edward S. Kim, and Waun Ki Hong
29 Chemoprevention of Oral Cancer: Risk Assessment, Plausible Intervention, and Monitoring ..... 383
Jon Sudb
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