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exile2004 发表于 2007-11-28 21:24

UbiG-methyltransferase请问是什么甲基转移酶?

请问UbiG-methyltransferase中的UbiG是什么意思?谢谢!

saturn100 发表于 2007-11-28 21:32

[s:103] 晕,不好意思,兄弟我也是作表观遗传学的,不过竟然没有没有听过有这种methyltransferase 我去给你查一下了

saturn100 发表于 2007-11-28 21:36

Wu, G., Williams, H. D., Zamanian, M., Gibson, F. & Poole, R. K.
(1992). Isolation and characterisation of Escherichia coli mutants
affected in aerobic respiration : the cloning and nucleotide
sequence of ubiG. Identi甤ation of an S-adenosylmethioninebinding
motif in protein, RNA and small-molecule methyltransferases.
J Gen Microbiol 138, 2101±2112.

和我猜的一样,是一种低等生物的methyltransferase,
In eukaryotes, the first O-methylation step
is carried out by the Coq3 polypeptide, which catalyzes the transfer of a methyl group from
S-adenosylmethionine to 3,4-dihydroxy-5-polyprenylbenzoate. In Escherichia coli, 2-polyprenyl-6-
hydroxyphenol is the predicted substrate; however, the corresponding O-methyltransferase has not been
identified. The second O-methylation step in E. coli, the conversion of demethylubiquinone to ubiquinone,
is carried out by the UbiG methyltransferase, which is 40% identical in amino acid sequence with the
yeast Coq3 methyltransferase.

exile2004 发表于 2007-11-28 22:04

谢谢:saturn100 我知道是一种酶,但是不知道是一种叫做什么—甲基转移酶?不是知道UbiG代表什么意思:Ubi 可能是 ubiquinone 但是不知道G代表什么意思?还是谢谢你了!

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