To investigate potential neurobiological functions of GPR88
[email=yangaiping0577@yahoo.com]yangaiping0577@yahoo.com[/email]一. Specific aims
We use genomic and molecular methods to investigate potential neurobiological functions of GPR88
二. Background and significances
Before we elucidation the construction of GPR88,let’s know what is GPR first.GPR is abbreviation to G-protein recepors.G-protein-coupled- receptors (GPCRs) are one of the most important drug discovery targets. GPCRs represent the most diverse group of proteins involved in transmembrane signaling pathways; they are activated by a wide variety of ligands, including peptide and nonpeptide neurotransmitters, hormones, growth factors, odorant molecules, and light.However ,GPR88 , a recepor whose location and similarity to ertain other recepors suggest that it may play a role in modulating motor function.GPR88 is expressed almost exclusively in the striatum,a region of the brian that becomes impaired with dopamine loss characterizing PD. The Entrez Gene funtion of GPR88 has showed below:
chromosome: 1; Location: 1p21.3See GPR88 in MapViewer
Gene sequence of GPR88 from GenBank Accession# is AB042407, AB042408, AB042409, AB042410, AB042407
To directly reveal the function of Strg/Gpr88 at the level of animal is essential to further study how it functions in human.
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