[Humana book]Innate Immunity (Infectious Disease (Totowa, N.J.).) 2002-11
Author: R. Alan B. Ezekowitz (Editor), Jules A. Hoffman (Editor)
URL:
http://www.amazon.com/exec/obido ... h=ASIN%2F1588290468
http://ec1.images-amazon.com/images/P/1588290468.01._SCLZZZZZZZ_.
pages: 432 pages
Publisher: Humana Press
ISBN: 1588290468
Average Customer Review: N/A
Format: PDF
Size: 6.92 Mb Approx
Edition: 1st Edition
Publication Date: November 2002
Supplier: Amazon
Summary:
..review of the innate immune system in plants, insects, and mammals, a discussion of the function of pattern recognition molecules in first-line host defense.
This book explores the host-pathogen interaction in plants, insects, and mammals to elucidate the origins of the human defense system against infection. Bringing together the latest research in the field of innate immunity, the authors review four significant research areas: plant immunity, invertebrate host defense immunity, pattern recognition receptors in mammalian host defense, and the links between innate and adaptive immunity in mammals. They find that the similarities among insect, plant, and mammalian immunological systems shed light on the complex mechanisms involved in adaptive immunity, thereby increasing our understanding of mammalian host defense.
Book Info:
Harvard Medical School, Boston, MA. Features a review of the innate immune system in plants, insects, and mammals, a discussion of the function of pattern recognition molecules in first-line host defense, new methods to explore and discover potential therapies, and the links between innate and adaptive immunity. DNLM: Immunity, Natural--physiology.
Contents
Preface...................................................................................................................v
Contributors....................................................................................................... ix
SECTION I: PLANT IMMUNITY
Section Editor: Frederick M. Ausubel
Introduction
Frederick M. Ausubel..........................................................................................1
1 Pathogen Recognition and Signal Transduction in Plant Immunity
Jonathan Cohn and Gregory B. Martin ..........................................................3
2 Plant Disease Resistance Genes
Jeffrey G. Ellis and David A. Jones................................................................27
3Nonhost Resistance in Plants to Microbial Pathogens
Michèle C. Heath...............................................................................................47
SECTION II: INVERTEBRATE HOST DEFENSE IMMUNITY
Section Editor: Jean-Marc Reichhart
Introduction
Jean-Marc Reichhart ........................................................................................59
4Regulatory Co-options in the Evolution of Deuterostome
Immune Systems
Ellen V. Rothenberg and Eric H. Davidson ..................................................61
5Antimicrobial Peptides in Insect Immunity
Philippe Bulet, Maurice Charlet, and Charles Hetru.................................89
6 Innate Immunity in the Horseshoe Crab
Shun-ichiro Kawabata, Tsukasa Osaki, and Sadaaki Iwanaga...............109
7 Pattern Recognition Receptors in Drosophila
Mika R鋗et, Alan Pearson, Kati Baksa, and Asha Harikrishnan ...........127
8Humoral and Cellular Responses in Drosophila Innate Immunity
Julien Royet, Marie Meister, and Dominique Ferrandon....................... 137
9 Thioester-Containing Proteins of Protostomes
Elena A. Levashina, Stéphanie Blandin, Luis F. Moita,
Marie Lagueux, and Fotis C. Kafatos.....................................................155
SECTION III: MAMMALIAN HOST DEFENSES: PATTERN RECOGNITION RECEPTORS
Section Editor: Siamon Gordon
Introduction
Siamon Gordon................................................................................................175
0 Toll-Like Receptors
Tsuneyasu Kaisho and Shizuo Akira ..........................................................177
1 The Macrophage Mannose Receptor and Innate Immunity
Thiruvamoor P. Ramkumar, Djilali Hammache,
and Philip D. Stahl.....................................................................................191
2 Diverse Roles of Lung Collectins in Pulmonary Innate Immunity
Erika C. Crouch and Jeffrey A. Whitsett ....................................................205
3 Structures of Complement Control Proteins
Thilo Stehle and Mykol Larvie.................................................................... 231
4 Lipopolysaccharide-Binding Protein and CD14
Peter S. Tobias.................................................................................................255
SECTION IV: MAMMALIAN HOST DEFENSES:
LINKS BETWEEN INNATE AND ADAPTIVE IMMUNITY
Section Editor: Steven L. Kunkel
Introduction
Steven L. Kunkel..............................................................................................267
5 The Role of Chemokines in Linking Innate and Adaptive Immunity
Cory M. Hogaboam and Steven L. Kunkel.................................................269
6 Antimicrobial Peptides
Tomas Ganz and Robert I. Lehrer................................................................287
7 The Role of Complement in Innate and Adaptive Immunity
Mihaela Gadjeva, Admar Verschoor, and Michael C. Carroll...............305
8 The Role of Natural Killer Cells in Innate Immunity to Infection
Wayne M. Yokoyama .....................................................................................321
9 Innate Immune Signaling During Phagocytosis
David M. Underhill.........................................................................................341
0 The Role of Mast Cells in Innate Immunity
Joshua A. Boyce and K. Frank Austen.........................................................361
1 CD1-Restricted T-Cells
D. Branch Moody ............................................................................................387
Index ..................................................................................................................403
Here's the Preface:
Preface
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent clonal response of adaptive immunity.
Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first-line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the inter-play between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action of pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. Innate Immunity aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man.
Innate Immunity is divided into four sections that focus on a combination of plant,
insect, and vertebrate systems to elucidate the origins of the human system of defense
against infection. We hope this book will further our understanding of the development
and functioning of the innate immune system.
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