1 学校和专业名称: 中国科学院上海生命科学研究院 细胞生物学 免疫调节机理及自身免疫性疾病
2 导师姓名:臧敬五
3 导师情况介绍:
mail地址
jwzang@sibs.ac.cn
通讯地址 上海市重庆南路225号
邮政编码 200025
Our most recent research interest is briefly described as follows:
Role of regulatory T cells in autoimmune conditions. Our research interest focuses on the basic mechanisms involved in the induction and conversion of CD4+CD25+ Treg by Copolymer-I (PNAS, 102: 6449-6454, 2005), gamma-interferon (JCI, In press, 2006) and T cell vaccination (PNAS, 103: 5024-5029, 2006). Using a humanized mouse model, our research expands to the role of thymus in the development and differentiation of CD4+CD25+ regulatory T cells. The other aspect of our research in this area is related to elucidation of signaling events involved and cytokines required for the function of CD4+CD25+ regulatory T cells in humans and rodents.
Role of autoreactive T cells in multiple sclerosis and rheumatoid arthritis and the development of novel treatment strategies to target at autoreactive T cells. Recently completed studies include: T cell receptor V gene analysis (Genes and Immunity, 6: 248-261, 2005), role of osteopontin as a key pro-inflammatory cytokine (JCI, 115: 1060-1067, 2005), involvement of MAPKK pathways (Journal of Immunology, 173: 7299-7307, 2004), functional properties of CD8+ autoreactive T cells (Journal of Immunology, 172: 5120-127, 2004) and stem cells (Brain, 127: 996-1008, 2004). Several lines of research are on-going to develop novel treatment strategies for MS and RA, which include T cell vaccination (Arthritis & Rheumatism and PNAS, 2006) and the use of neural stem cells or anti-inflammatory small molecules from Chinese herbal medicine.
获奖情况
1991, Research Fellowship Award, National Multiple Sclerosis Society, USA
1993, Achievement Award and the Prize of the Belgian Society for Clinical Immunology, Belgium
1994, International Award for Genetics in Autoimmune Diseases, Italy
1999, George W. Bush Research Award, National Multiple Sclerosis Society, USA
2004, The Outstanding and Contributory Foreign Experts to Shanghai
2005, The Third Prize of Shanghai Scientific Technology Progress
2005, The Second Prize of Debio-CCRF China Award
2005, Shanghai White Magnolia Award
指导研究
生情况 目前在学硕士生:3人;博士生人数:6人
个人简介
上海第二医科大学 本科,硕士研究生
比利时布鲁塞尔大学免疫学博士
美国Harvard大学医学院博士后
美国Baylor医学院神经学系、免疫学系教授
美国德州执照医师(Texas State Board of Medical Examiners)
中国科学院上海生命科学院/上海交通大学医学院健康科学研究所所长
近期论文
1. Zhaojun Wang, Jian Hong, Wei Sun, Guangwu Xu, Ningli Li, Xi Chen, Ailian Liu, Lingyun Xu, Bing Sun, Jingwu Z Zhang. Role of g-Interferon in Induction of Foxp3 and Conversion of CD4+CD25- T cells to CD4+ Regulatory T Cells. Journal of Clinical Investigation. 2006 Sep 1;116(9):2434-2441.
2. Jian Hong, Ying Zang, Hong Nie and Jingwu Zhang. CD4+ Regulatory T Cell responses induced by T cell vaccination in patients with multiple sclerosis. Proceedings of National Academy of Science USA 103:5024-5029, 2006
3. Guangwu Xu, Hong Nie, Ningli Li, Wenxin Zheng, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Jian Hong, Jingwu Zhang. Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. Journal of Clinical Investigation 115(4):1060-1067, 2005
4. Jian Hong, Ningli Li, Xuejun Zhang, Biao Zheng, Jingwu Zhang. Induction of Expression of Transcription Factor FoxP3 and Function of CD4+CD25+ Regulatory T Cells. Proceedings of National Academy of Science USA 102(18):6449-6454, 2005
5. Xu G, Sun W, He D, Wang L, Zheng W, Nie H, Ni L, Zhang D, Li N, Jingwu Zhang. Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism. Journal of Rheumatology 32:410-416, 2005
6. Wei Sun, Hong Nie, Ningli Li, Ying Zang, Dongqing Zhang, Guozhang Feng, Liqing Ni, Rong Xu, Sarvamangala Prasad, Rachel R Robinson, Walter Ho, Eli Sercarz, Jingwu Zhang. Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis. Genes and Immunity 6:248-261, 2005
7. Wei Sun, Uday Popat, George Hutton, Ying CQ Zang, Geoffrey Land, Robert Krance, George Carrum, Geoffrey A. Land, Helen Heslop, Malcolm Brenner, Jingwu Zhang. Characteristics of T Cell Receptor Repertoire and Myelin-Reactive T Cells Reconstituted from Autologous Hematopoietic Stem Cell Grafts in Multiple Sclerosis. Brain 127(5):996-1008, 2004.
8. Rana AK Singh and Jingwu Zhang. Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. Journal of Immunology 173(12):7299-307, 2004
9. Ying C. Q. Zang, Sufang Li, Victor M. Rivera, Jian Hong, Rachel R. Robinson, Wini T. Breitbach, James Killian, Jingwu Zhang. Increased CD8+ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis. Journal of Immunology 172:5120-5127, 2004.