Progress in Medicinal Chemistry : Volume 41 (Progress in Medicinal Chemistry)
Progress in Medicinal Chemistry : Volume 41 (Progress in Medicinal Chemistry)
By F.D., Ed. King
* Publisher: Elsevier Science
* Number Of Pages: 300
* Publication Date: 2003-04-01
* ISBN-10 / ASIN: 0444511423
* ISBN-13 / EAN: 9780444511423
* Binding: Hardcover
Book Description:
Hardbound. This volume features:
%26#8226; A comprehensive account of in vitro and in vivo models and in silico approaches for the prediction of oral absorption and bioavailability.
%26#8226; The application of virtual screening of virtual libraries as a means of identifying lead molecules for drug discovery programmes.
%26#8226; The development of molecular probes targeted to inhibit %26amp;ggr;-secretase, a key enzyme involved in the production of %26amp;bgr;-amyloid proteins the accumulation of which has been implicated as a cause of Alzheimer's disease.
%26#8226; The discovery and evaluation of 5-HT terminal autoreceptor antagonists, an approach that may provide a novel treatment of depression.
%26#8226; A survey of orally acting %26amp;bgr;3-agonists for the treatment of type II diabetes and obesity from early compounds active only in rodent models to recent drugs with therapeutic potential in man.
%26#8226; Antagonists
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